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Educational Articles

Dogs + Medications & Supplements

  • Dinotefuran/permethrin/pyriproxyfen (brand name Vectra 3D®) is a topical (spot-on) antiparasitic drug that is applied directly to the skin. It is used to repel and kill fleas, ticks, mosquitoes, biting flies, sand flies, and biting/chewing lice in dogs and puppies that are at least 8 weeks of age and weigh at least 2.3 kg (5 lb). NEVER use in cats and avoid using in households with cats, if possible. Permethrin is poisonous to cats and any exposure may be fatal.

  • Dinotefuran/pyriproxyfen (brand name Vectra) is a topical (spot-on) antiparasitic drug used to repel and kill fleas in dogs and puppies that are at least 8 weeks of age and weigh at least 1.14 kg (2.5 lbs) and in cats and kittens that are at least 8 weeks of age and weigh at least 0.9 kg (2 lbs). Do not confuse this medication with Vectra 3D®, a similar product labeled for use in dogs only.

  • Diphenhydramine is given by mouth or as an injection and is used on and off label to treat allergic reactions, motion sickness, and to induce sedation. Side effects include sleepiness, and less commonly dry mouth and gastrointestinal upset. Diphenhydramine should not be used in pets that are allergic to this medication and should be used cautiously in pets with glaucoma, enlarged prostate, thyroid or heart disease, or are lactating. If a negative reaction occurs, please call your veterinary office.

  • Diphenoxylate + atropine (brand name Lomotil) is an opioid combination medication used to treat diarrhea or coughing in dogs and diarrhea in cats. Its use in cats is not generally recommended. Diphenoxylate + atropine is given by mouth in the form of a tablet or liquid. This article discusses administration, potential side effects, risks, and monitoring.

  • Dorzolamide is applied to the eye and is used off label to treat glaucoma (increased eye pressures). Give as directed by your veterinarian. Common side effects include stinging sensation, eye redness, watery eyes, and light sensitivity. Do not use in pets that are allergic to it or sulfonamides. If a negative reaction occurs, please call your veterinary office.

  • Doxepin is given by mouth and is used off label to treat psychogenic dermatoses such as excessive grooming and psychogenic alopecia. Give as directed. The most common side effect is sleepiness. Do not use in pets that are allergic to it or other tricyclic antidepressants, in pets currently using an MAOI or flea/tick collar, or in pets undergoing skin allergy testing within two weeks. If a negative reaction occurs, please call your veterinary office.

  • Doxycycline is an antibiotic given by mouth in the form of a tablet, capsule, or liquid, used off label to treat certain infections. Common side effects include stomach upset, sun sensitivity, and increases in liver enzymes. Serious side effects include liver failure, seizures, and trouble swallowing. Do not use in pregnant pets and use cautiously in pets with liver disease or in young pets. If a negative reaction occurs, please call your veterinary office.

  • Echinacea is given by mouth and is used over the counter and off label to improve immune system function and reduce inflammation. Give as directed by your veterinarian. Side effects are uncommon but may include vomiting and diarrhea. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.

  • Enalapril is used on and off label and is given by mouth or injection to treat heart failure, high blood pressure, chronic kidney disease, or proteinuria. Common side effects include loss of appetite, vomiting, diarrhea, and tiredness. Do not use in pets that are allergic to it, have an acute kidney injury, or have certain heart conditions. If a negative reaction occurs, please call your veterinary office.

  • Enilconazole is a topical wash/dip used to treat dermatophytosis (ring worm) in dogs and sometimes in cats. Side effects are uncommon as it is relatively well-tolerated, but in cats may include drooling, vomiting, lack of appetite, weight loss, muscle weakness, and elevated liver enzymes. Do not use in cats unless directed by your veterinarian. If a negative reaction occurs, please call your veterinary office.