Educational Articles
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Imipramine is given by mouth or injection and is used off label to treat behavior disorders, sudden loss of muscle tone, urinary incontinence, cancer pain, and other conditions. Give as directed by your veterinarian. Common side effects include sleepiness, dry mouth, and constipation. Do not use in pets that are allergic to it or other tricyclic antidepressants, pets currently using MAOIs, or pets that are pregnant or nursing. If a negative reaction occurs, please call your veterinary office.
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Insulin is used on and off label and injected under the skin to treat diabetes, ketoacidosis, and high potassium levels. Side effects may include low or high blood sugar levels, insulin resistance, and skin allergic reactions to the injections. Do not use in pets who are having an episode of low blood sugar levels and do not use pork insulins in pets with a pork allergy. If a negative reaction occurs, please call your veterinary office.
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Insulin glargine is an injectable medication used in cats, dogs, ferrets, guinea pigs, and horses with diabetes mellitus. It is used to lower blood sugar levels and for long-term maintenance therapy of diabetes mellitus. Monitor closely for signs of low blood sugar (weakness, lack of energy, lethargy, stumbling or difficulty walking, behavior changes, muscle twitching, seizures, and/or unresponsive).
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Lente (porcine zinc) insulin (brand names Vetsulin®, Vetpen®) is an injectable medication approved for use in cats and dogs with diabetes mellitus. It is used to lower blood sugar levels and for long-term maintenance therapy of diabetes mellitus. This medication may be used "off label" or "extra label" in ferrets. Monitor closely for signs of low blood sugar (weakness, lack of energy, lethargy, stumbling or difficulty walking, behavior changes, muscle twitching, seizures, and/or unresponsiveness).
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NPH (Neutral Protamine Hagedron) insulin is an injectable medication used in cats, dogs, birds, ferrets, and horses with diabetes mellitus. It is used to lower blood sugar levels and for long-term maintenance therapy of diabetes mellitus. Monitor closely for signs of low blood sugar (weakness, lack of energy, lethargy, stumbling or difficulty walking, behavior changes, muscle twitching, seizures, and/or unresponsiveness).
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Protamine zinc (PZI) insulin (brand name Prozinc®) is an injectable medication approved for use in cats and dogs with diabetes mellitus. It is used to lower blood sugar levels and for long-term maintenance therapy of diabetes mellitus. This medication may be used “off label” or “extra label” in other species. Monitor closely for signs of low blood sugar (weakness, lack of energy, lethargy, stumbling or difficulty walking, behavior changes, muscle twitching, seizures, and/or unresponsiveness).
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Interferon alfa is given by mouth or injection and is used off label to treat certain viral diseases in dogs and cats. Give as directed by your veterinarian. Side effects are uncommon but may include vomiting or decreased appetite. Do not use in pets that are allergic to it or that are receiving immediate vaccination. If a negative reaction occurs, please call your veterinary office.
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Itraconazole is given by mouth in the form of a capsule, tablet, or liquid to treat fungal infections in cats and for off label treatment in dogs and small mammals. The most common side effects are anorexia, vomiting, liver toxicity, skin lesions, or limb and vessel swelling. It should not be used in pets with liver disease or low stomach acid production, and used with caution in pregnant, lactating, or pets with heart disease. If a negative reaction occurs, call your veterinary office.
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Ivermectin is most commonly used as a heartworm preventive in dogs and cats. It also used off label for treating a variety of internal and external parasites. Ivermectin may be combined with other deworming medications. Ivermectin is available as tablets, chewable tablets, a topical liquid (for ear mite treatments), and an injectable that your veterinarian will administer. Some breeds of dogs (e.g., collies, sheepdogs, and collie- or sheepdog-cross breeds) are more sensitive to ivermectin than others. There are some medications that interact with ivermectin, so it is important to tell your veterinarian about all medications your pet is taking. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.
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This handout outlines the use of disease-modifying osteoarthritis drugs (DMOADs) in cats, specifically the use of polysulfated glycosaminoglycans (PSGAGs). The rationale for their use, potential side effects, and treatment expectations are explained.