Educational Articles
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Methocarbamol is given by mouth or injection and is used on and off label to treat muscle spasms due to injury, inflammation, or certain toxicities. Give as directed by your veterinarian. The most common side effect includes sleepiness. Do not use methocarbamol in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.
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Methylprednisolone is given by mouth or injection and is used on and off label to treat inflammatory, immune-mediated, or hormonal conditions. Common side effects include increased drinking, urination, and appetite, dull/dry haircoat, and/or weight gain. Do not use in pets that are allergic to it, receiving NSAIDs, that are recovering from a recent surgery, or in pets with systemic fungal or viral infections, diabetes, Cushing’s disease, stomach or intestinal ulcers. If a negative reaction occurs, please call your veterinary office.
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Metoclopramide is given by mouth or injection and is used off-label to treat gastrointestinal motility disorders, nausea, and vomiting in dogs, cats, and other animals. Give as directed. Side effects are uncommon but may include restlessness, hyperactivity, muscle twitches, drowsiness, and increased urination. Do not use in pets with intestinal blockage or bleeding, pseudopregnancy, pheochromocytoma, or a history of seizures or head trauma. If a negative reaction occurs, contact your veterinarian.
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Metronidazole is given by mouth or injection and is used off-label to treat certain anaerobic bacterial and protozoal infections and gastrointestinal conditions in dogs, cats, and other animals. Give as directed. Side effects may include nausea, vomiting, diarrhea, regurgitation, decreased appetite, tiredness, and drooling. Do not use in pets that are allergic to it, are debilitated, or are pregnant or nursing. If a negative reaction occurs, contact your veterinarian.
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Mexiletine is given by mouth and is used off label to treat abnormal heart rhythms and muscle disorders in dogs. Common side effects include stomach upset such as vomiting, trembling, or dizziness. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.
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Midazolam is a benzodiazepine used for its sedative, anti-anxiety, and muscle relaxant properties. It is primarily used as a sedative before surgery and to stop seizures. It is used “off label” or “extra label” in animals. This medication is a controlled substance primarily given via injection by your veterinary team, though it may be prescribed to your pet for intranasal or intrarectal administration at home.
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Milbemycin oxime is a heartworm disease preventive and treats internal parasites (e.g., hookworms and roundworms) in dogs and cats. It is also found in combination products with other drugs. It is also used off label to treat infestations in dogs. Milbemycin is given by mouth with a flavored oral tablet. At regular doses, milbemycin is well-tolerated; when used at higher doses for treating mites, side effects have been observed. Some breeds of dogs (e.g., collies, sheepdogs, and collie- or sheepdog-cross breeds) are more sensitive to milbemycin than others; your veterinarian will advise you on the safety of milbemycin use in your dog. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.
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Milbemycin oxime + afoxolaner is a heartworm disease preventive that also treats certain internal parasites and controls fleas and ticks in dogs. It is also used off-label to treat mite infestations in dogs. This combination drug is given by mouth as a flavored chew tablet. Certain dog breeds are more sensitive to milbemycin oxime than others; your veterinarian will advise you on the safety of milbemycin oxime use in your dog. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.
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Milbemycin oxime + lufenuron is a heartworm disease preventive that also treats internal parasites (e.g., whipworms, hookworms, and roundworms) and controls flea populations in dogs. Milbemycin oxime + lufenuron is given by mouth as a flavored chew tablet. At prescribed doses, this medication is well-tolerated; when used off-label at higher doses for treating mites, side effects have been observed. Your veterinarian will advise you on the safety of milbemycin oxime + lufenuron use in your dog. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.
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Milbemycin oxime + lufenuron + praziquantel is a heartworm disease preventive that also treats certain internal parasites and controls fleas in dogs. This combination medication is given by mouth as a flavored chew tablet. At prescribed doses, this medication is well-tolerated. Certain dog breeds are more sensitive to milbemycin than others; your veterinarian will advise you on the safety of milbemycin use in your dog. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.