Educational Articles
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Gastroesophageal reflux disease (GERD) is a chronic condition in which stomach acid flows from the stomach to the esophagus. In dogs with GERD, stomach acid passes through the lower esophageal sphincter and enters the esophagus. Possible signs associated with GERD include decreased appetite, difficulty swallowing, licking the lips, change in bark, chronic cough, appearance of generalized discomfort, pacing, or restlessness at night. Gastrointestinal reflux disease is often diagnosed on the basis of endoscopy. There are a number of different treatments for GERD. Most dogs require a combination of treatments, each of which addresses the problem differently. Most dogs experience a rapid improvement in clinical signs with treatment.
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Gastrointestinal endoscopy uses a flexible tube with a camera or viewing port to inspect the esophagus, stomach, proximal small intestine, or colon for evidence of disease-causing clinical signs characteristic of gastrointestinal disease. Foreign bodies can often be retrieved. Biopsies are taken of abnormal and normal tissue, as not all conditions cause gross changes to the stomach or intestinal surface. The endoscope cannot reach all areas of the small intestine, so other tests may be needed to diagnose disease in these areas. Endoscopic pinch biopsies are not full thickness so if diagnosis is not achieved with endoscopic biopsies, additional testing including surgical biopsies may be needed. 12-18 hours fasting and enemas are required prior to endoscopy depending on the area being studied.
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A gastropexy is a surgical procedure that is sometimes performed in large-breed dogs to prevent gastric dilatation and volvulus (GDV), also known as bloat – a life-threatening condition. This handout explains how the procedure works, how it is used preventatively and in emergency situations, risk factors, and post-operative care.
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Gastrostomy tubes are placed through the skin of the abdomen into the stomach to enable long-term nutrition in dogs that either refuse to eat or are unable to chew and swallow food. A special liquid diet or homemade mixture liquefied with water will be recommended by your veterinarian. Step-by-step instructions are provided. The decision to remove the tube will be determined by your veterinarian.
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Genetic (DNA) testing is readily available, whether you are using it for fun to find out what breeds your pet is made up of or if you are looking into possible medical conditions. DNA samples can be collected either from a cheek swab or a blood draw. Knowing which breeds your pet is made up of can help you and your veterinarian prevent or prepare for health issues in the future.
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All dogs evolved from a common ancestor and over the course of tens of thousands of years, evolution (mainly driven by humans looking for specific behaviors and characteristics) created the multitude of breeds in existence today. Humans started breeding dogs for pleasure in the 19th century and this led to dog shows and an intense diversification of the dog species into over 400 breeds recognized today. DNA tests can be performed on mixed breed dogs to determine their breed ancestry.
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Despite the huge variety in coat color, there are only two basic pigments that determine the color of canines: eumelanin (black) and phaeomelanin (red). All different variations in color are created by these two pigments, which are both forms of melanin. This handout discusses the details of genetics and coat color selection.
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There are multiple methods of inheritance including autosomal dominant, autosomal recessive and sex-linked inheritance that determine which characteristics (or phenotypes) are displayed by the offspring. There are also many polygenic traits (i.e., associated with multiple genes) as well as environmental factors that make prediction of disease or likelihood of passing disease onto offspring much more complicated.
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Mutations are errors made during DNA replication. Mutations can be acquired as cells divide within the body or can be inherited if the parent’s DNA contains a mutation. Acquired mutations can arise spontaneously or can be triggered by external factors. Effects of mutation depend on what area of the DNA has been altered and can range from no effect to severe effects such as cancer development. Genetic markers can be used to determine genetic heritage such as breed origins.
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Deoxyribonucleic acid (DNA) is a long molecule that contains an animal’s entire genetic code. DNA is primarily located within the nucleus of each cell. In the nucleus, enzymes transcribe the DNA bases into a substance called RNA (ribonucleic acid), which serves as a messenger, taking the DNA message out into the cytoplasm of the cell where the RNA is translated into proteins. These proteins are responsible for a number of functions in the cell and throughout the body, primarily by acting as enzymes that regulate various cell reactions. DNA tests allow us to examine an animal’s DNA in order to see whether they carry certain genetic diseases. DNA testing can also be used to determine the ancestry of an animal.