Educational Articles
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Dermatomyositis is hereditary, immune-mediated disease of the skin muscles and blood vessels affecting primarily collies, Shetland Sheepdogs and mixes of these breeds. Other breeds can experience similar disease. Signs are usually first recognized in puppies but can present in young adulthood. Signs include: skin lesions (crusty erosions, patchy alopecia or ulcers) around the eyes, lips, face, ear flaps or tail tip, foot pad lesions; atrophy of chewing muscles or difficulty chewing; stiff gait and megaesophagus in severely affected dogs. Skin biopsies are diagnostic. Treatment involves treating secondary bacterial infections, reducing sun exposure, EFAs, and immunomodulatory medications including tetracycline, niacinamide, pentoxifylline, cyclosporine and corticosteroids. Prognosis varies depending on severity.
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This handout discusses the growing trend for designer dog breeds – the crossing of pure dog breeds to create dogs that combine “the best of both worlds.” The pros and cons of this practice are highlighted, along with some of the more common designer breeds currently available.
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Desmopressin is administered into the eye or is given as an injection and is used off label to treat diabetes insipidus and von Willebrand disease. Give as directed by your veterinarian. Side effects are uncommon but may include irritation upon application to the eye. Do not use in pets that are allergic to it or pets that are prone to blood clots, such as those with heart disease. If a negative reaction occurs, please call your veterinary office.
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Desoxycorticosterone pivalate (DOCP) (brand name Percorten-V®, Zycortal®) is a steroid hormone replacement therapy used to treat primary hypoadrenocorticism (Addison’s disease) in dogs. Extra-label (off-label) lower dosages of DOCP (i.e., lower dose, longer dosing interval, or both) can be used to control the balance of blood electrolyte levels. DOCP has also been used extra-label to treat hypoadrenocorticism in cats.
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Dexamethasone is given on and off label, by mouth or injection, to treat various inflammatory, autoimmune, and adrenal gland conditions. It can also be used off label as a diagnostic test. Common side effects include increased drinking, urination and/or appetite, dull/dry haircoat, weight gain, pot-bellied appearance, muscle weakness, panting, vomiting, or diarrhea. Do not use in pets that are allergic to it, have systemic fungal infections, diabetes, or stomach or intestinal ulcers, or are taking NSAIDs. It should not be used in rabbits or in surgical pets. If a negative reaction occurs, please call your veterinary office.
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Dexamethasone ophthalmic is a topical steroid medication used to treat inflammatory eye conditions in cats, dogs, rabbits, avian species, and other animals. Dexamethasone ophthalmic may be used alone or in combination with an antimicrobial. Dexamethasone ophthalmic comes in ointment and liquid drop form. Avoid use in animals with corneal ulcerations or corneal infections.
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Dexamethasone is used to test the level of cortisol hormone in the body. Injection of dexamethasone will cause a decreased level of cortisol in a normal pet; however, in a pet with Cushing's disease, there is minimal or no decrease in cortisol level. Other diseases can suppress cortisol production, so it is important to rule these out prior to dexamethasone testing. Knowing the type of Cushing's disease your pet has can guide treatment decisions and offers a more defined prognosis.
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Dexmedetomidine is a sedative/tranquilizer used primarily in cats and dogs as a pre-medication injection for anesthesia or for chemical restraint. It is also used orally in dogs for short-term anxiety management. The most common side effect is a low heart rate. Dexmedetomidine should not be used in patients with severe heart liver or kidney disease. It should be used cautiously in young, old, or weak animals. Consult your veterinary office immediately if you suspect a negative reaction or overdose.
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Dextromethorphan is given by mouth and is used off label to treat compulsive behaviors and occasionally used to treat cough. Side effects are uncommon but may include vomiting, diarrhea, decreased appetite, sleepiness, drooling or anxiousness. Do not use in pets that are allergic to it. If a negative reaction occurs, please call your veterinary office.
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Dextromethorphan + Guaifenesin is given by mouth as a tablet and is used off label to reduce cough in dogs and cats or to treat compulsive behavior. Side effects are uncommon, but serious adverse reactions associated with this drug may occur without warning. Contact your veterinarian if you notice anything out of the ordinary.