Educational Articles
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Serum biochemistry measures the amount of enzymes, proteins, sugar, electrolytes, minerals, and hormones found in the liquid portion of the blood. Testing for these substances provides information about the body’s organs and tissues, as well as the metabolic state of the animal. This article provides general information on the most routinely measured factors in serum and common reasons for abnormal readings.
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Electrolytes are the salts and metallic components that are dissolved within the blood serum (serum is the liquid portion of blood). The electrolytes of greatest clinical importance are sodium, potassium, chloride, bicarbonate, phosphorus, and calcium. It is important to detect changes in electrolyte concentrations so that these changes can be treated before the situation becomes severe or life-threatening.
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Serum iron tests are indicated when the results from a complete blood count indicate that your pet is anemic and that the red blood cells are microcytic and hypochromic. Because blood is a rich source of iron, chronic external blood loss can lead to iron deficiency anemia. Tests to assess iron deficiency require a single blood sample that is sent to a veterinary referral laboratory. Additional tests such as serum biochemistry profile, urinalysis, and fecal evaluation are also used as screening tests to determine the cause or source of the chronic blood loss.
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Serum contains a large number of proteins that perform diverse functions which include providing cellular nutrition, defending against infections, playing a role in inflammation, and acting as hormones or enzymes. Protein electrophoresis is a specialized test that analyzes specific groups of proteins in the blood serum and measures how much of each group of protein is present. The results of the analysis help diagnose specific diseases, such as infection and some types of cancer.
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A biopsy is one of the more common diagnostic procedures performed in dogs. Biopsies provide valuable insight into the type of cells in an abnormal area of skin or a skin growth and whether the growth poses a more serious health threat to your pet. Either the entire mass or a small representative section of skin is removed and submitted to a veterinary pathologist, who will perform a histopathology analysis. The pathologist will attempt to determine the nature of the lesion, identify the type of cells and their relationship to each other, as well as any evidence of malignancy.
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Addison’s disease, or hypoadrenocorticism, results from decreased corticosteroid and mineralocorticoid production from the adrenal glands. This results in non-specific signs of illness that mimic many other diseases. This article outlines screening and diagnostic tests for Addison’s disease.
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Abdominal enlargement in dogs may occur due to a simple cause such as obesity, pregnancy, or intestinal parasites; however, it can also be a sign of different illnesses including hyperadrenocorticism, hypothyroidism, heart disease, organ enlargement trauma, GDV, and cancer. Identifying the cause of abdominal enlargement can take several steps starting with history and physical exam, progressing to screening tests including bloodwork and urinalysis. The CBC is assessed for signs of anemia, low platelets, or signs of inflammation. A biochemistry profile may reveal liver or kidney dysfunction, hypo- or hyperproteinemia, hypoglycemia, or other abnormalities. Urinalysis is used to fully interpret the biochemistry and check for abnormal urinary sediment. Based on the findings of the screening tests, additional diagnostics may include imaging, EKG, tissue biopsy, or fluid analysis.
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Coughing can have many different causes, including infectious disease, heart disease, inflammatory conditions, anatomical abnormalities, or cancer. Important for the diagnosis is a thorough history, physical exam, and screening tests, outlined here. More advanced diagnostics are also summarized.
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Listlessness and inappetence are vague signs that can occur in pets for many reasons, both physical and mental. Conditions that produce these signs include grief, anxiety, oral disease, organ dysfunction, and cancer. Diagnosis starts with taking a thorough history and physical exam and may progress to screening tests including a CBC, biochemistry profile, and urinalysis. Other diagnostic tests that may be needed include hormonal tests, liver function tests, imaging (radiographs or ultrasound), culture and sensitivity, or specific tests for infectious diseases or immune mediated disease.
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Diarrhea can be a simple diagnosis or a complex one. A thorough history and physical exam may be enough to determine the cause; however, in less obvious cases, various tests may be needed. Pending the results, a treatment plan can be developed.