Educational Articles
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All dogs evolved from a common ancestor and over the course of tens of thousands of years, evolution (mainly driven by humans looking for specific behaviors and characteristics) created the multitude of breeds in existence today. Humans started breeding dogs for pleasure in the 19th century and this led to dog shows and an intense diversification of the dog species into over 400 breeds recognized today. DNA tests can be performed on mixed breed dogs to determine their breed ancestry.
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Despite the huge variety in coat color, there are only two basic pigments that determine the color of canines: eumelanin (black) and phaeomelanin (red). All different variations in color are created by these two pigments, which are both forms of melanin. This handout discusses the details of genetics and coat color selection.
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There are multiple methods of inheritance including autosomal dominant, autosomal recessive and sex-linked inheritance that determine which characteristics (or phenotypes) are displayed by the offspring. There are also many polygenic traits (i.e., associated with multiple genes) as well as environmental factors that make prediction of disease or likelihood of passing disease onto offspring much more complicated.
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Mutations are errors made during DNA replication. Mutations can be acquired as cells divide within the body or can be inherited if the parent’s DNA contains a mutation. Acquired mutations can arise spontaneously or can be triggered by external factors. Effects of mutation depend on what area of the DNA has been altered and can range from no effect to severe effects such as cancer development. Genetic markers can be used to determine genetic heritage such as breed origins.
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Deoxyribonucleic acid (DNA) is a long molecule that contains an animal’s entire genetic code. DNA is primarily located within the nucleus of each cell. In the nucleus, enzymes transcribe the DNA bases into a substance called RNA (ribonucleic acid), which serves as a messenger, taking the DNA message out into the cytoplasm of the cell where the RNA is translated into proteins. These proteins are responsible for a number of functions in the cell and throughout the body, primarily by acting as enzymes that regulate various cell reactions. DNA tests allow us to examine an animal’s DNA in order to see whether they carry certain genetic diseases. DNA testing can also be used to determine the ancestry of an animal.
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Gentamicin ophthalmic is used in the eye to treat bacterial infections and end-stage glaucoma. Side effects may include increased redness or eye irritation. Do not use this medication if your pet is allergic to it or has a full thickness wound to the eye. If a negative reaction occurs, call your veterinary office.
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Gentamicin topical formulations are used to treat bacterial infections. The ophthalmic formulation is used off label to treat external ear infections by topically applying the medication directly to the ear canal. Side effects may include increased redness or inflammation. If these effects occur, discontinue the medication and call your veterinarian. If you suspect an overdose or an adverse reaction to the medication, call your veterinary office immediately.
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If you are planning to add another dog to your family, take time to consider the personality, size, and sex of your current household dog. Introduce the dogs gradually, watching for subtle signs of fear or aggression. Supervise the dogs for as many weeks as needed to assure long term success.
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When you bring a new puppy into your home, there is inevitably a period of adjustment. The adjustment will be easier if you plan how you will meet the puppy's needs and provide a positive experience, safe socialization, supervision, and structure. Puppies can be exhausting at times, but raising a puppy is intensely rewarding.
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Giardiasis is an intestinal infection caused by a microscopic protozoan. These parasites attach themselves to the intestinal wall and the damage causes an acute, sudden onset of foul-smelling diarrhea. Diagnosis may be by routine fecal flotation or presumptively based on clinical signs. Fenbendazole and metronidazole are the drugs most commonly used to treat giardiasis.