Educational Articles
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The most common disorder of the thyroid gland in dogs is hypothyroidism. Diagnosis of hypothyroidism includes a complete blood count, biochemistry profile, urinalysis, and thyroid-related hormones. Mild anemia, elevated cholesterol and mildly elevated liver and kidney enzymes are supportive of a diagnosis of hypothyroidism. A combination of clinical signs and measurements of total T4, free T4 by equilibrium dialysis, and thyroid stimulating hormone (TSH) is generally used to confirm a diagnosis.
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Trypsin-like immunoreactivity (TLI) is a blood test that measures the amount of a pancreatic proenzyme called trypsinogen. This measurement correlates with the amount of pancreatic enzymes released into the intestine to aid in digestion. A low measurement indicates exocrine pancreatic insufficiency. Concurrent pancreatitis or tests done shortly after a meal may temporarily increase this measurement to a normal value (false negative).
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Damage to the tympanic membrane and middle ear infections can be very painful for dogs and cause a variety of clinical signs affecting the skin and nervous system. Diagnosis often requires a thorough ear examination with testing while your dog is under sedation or anesthesia. The treatment methods and prognosis depend on the nature of your dog's condition.
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Ultrasound uses the reflection of sound waves to generate an image of internal structures allowing for identification of masses, pregnancy diagnosis, abnormal heart function and muscle size, abnormalities of the orbit, and abnormal appearance of abdominal organs. It cannot be used to identify abnormalities in areas of air such as the lungs, or areas surrounded by bone. B-Mode generates a 2-dimensional image, while M-Mode can be used to trace structures in motion and is often used in ultrasound evaluation of the heart. Doppler can be used to identify speed and direction of fluid flow such as blood flow. Anesthesia is generally not needed unless tissue biopsies are planned. Shaving of fur is recommended to allow best contact of the probe with the skin to produce the most diagnostic images. Ultrasound results can be analyzed in real time; however, assessment by a radiologist may take several days. Ultrasound is an invaluable tool to detect problems in a non-invasive fashion.
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Urinalysis is an important part of any comprehensive workup or health screen as it provides information on the urinary system including the kidneys and bladder and also can support diagnosis of metabolic disease such as diabetes mellitus. Urine collection methods include cystocentesis, catheterization, or mid-stream free flow, each of which has their own pros and cons. Urine samples are assessed using the following parameters: appearance (color and turbidity), concentration assesses how the urine has been concentrated by the kidneys, urine dipsticks (assess pH, glucose, protein, blood, ketones, urobilinogen, and bilirubin), and microscopic exam of sediment (may reveal the presence of abnormal cells including red blood cells, white blood cells, and tissue cells or crystals). A cytological preparation of sediment may be recommended to look at tissue cells in more detail.
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Cortisol is a stress hormone that is excreted from the body in the urine. Creatinine is a product of muscle metabolism and is normally lost in the urine at a relatively steady rate. The ratio of creatinine to cortisol in the urine can be used to account for the effect of urine concentration on cortisol measurements. Urine cortisol/creatinine ratio is usually evaluated in animals suspected of having Cushing's disease. This test involves the collection of a single urine sample, taken first thing in the morning.
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The presence of protein in urine is called proteinuria, and it may indicate that the kidneys are not working properly. In some situations, proteinuria may even be a sign of kidney failure; however, bleeding or inflammation in the urinary system is a far more common cause. Your veterinarian may recommend further testing if the urinalysis reveals inflammation or bleeding.
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The urine protein/creatinine (UPC) ratio is a test that measures how much protein is being lost through the kidneys. The UPC measures whether protein excretion is greater than expected when compared to the excretion of creatinine. Before the UPC ratio can be interpreted, two other measures of kidney function should be taken: blood urea nitrogen (BUN) and serum creatinine.
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Von Willebrand's disease causes an inability for blood to clot resulting in excessive bleeding. If this disease is suspected, initial screening tests include a complete blood count (CBC), buccal mucosal bleeding time, and a coagulation profile. More advanced diagnostics include assays that assess the quantity and functionality of vWF. DNA testing is available and most commonly used to evaluate animals used in breeding programs.
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Regular preventive health care for your dog can increase the length and quality of her life. Health care guidelines are established and kept up to date using the most recent evidence-based recommendations including the recommendation that all dogs receive a complete veterinary examination at least once a year or more frequently, depending on their individual needs and health concerns.